The Hang Seng Index dropped 0.1 per cent to 26,797.05 at the open, after falling 0.2 per cent Tuesday. The Hang Seng Tech Index fell 0.9 per cent. On the mainland, the CSI 300 Index lost 0.3 per cent and the Shanghai Composite Index slipped 0.1 per cent.
Limiting losses, gold miner Zijin Mining Group rose 2.1 per cent to HK$42.24, while oil and gas producer CNOOC added 2 per cent to HK$23.82.
US equities fell overnight, with the S&P 500 dropping 0.8 per cent and the Nasdaq sliding 1.4 per cent, as concerns grew that an acceleration in artificial intelligence investment could weigh on demand for related products, such as software. Risk sentiment was further dented by escalating tensions between the US and Iran.
One stock debuted on Wednesday. Qingdao Gon Technology jumped 25 per cent to HK$45.